Distribution of DHPS Mutations Among ITS Subtypes of P. carinii
نویسندگان
چکیده
Sulfa drugs are widely used in the prophylaxis and treatment of Pneumocystis carinii pneumonia. Co-trimoxasole, the first-line agent, is a combination of sulfamethoxazole plus trimethoprim but functions as sulfa monotherapy since trimethoprim appears to be inactive. Dapsone, a sulfone, is a commonly used second line agent. Both sulfamethoxazole and dapsone act by binding to the dihydropteroate synthase (DHPS) (reviewed in ref [2, 16] (Fig. 1).
منابع مشابه
Distribution of DHPS mutations among ITS subtypes of P. carinii f. sp. hominis.
Sulfa drugs are widely used in the prophylaxis and treatment of Pneumocystis cnrinii pneumonia. Co-trimoxazole, the first-line agent, is a coinbination of sulfamethoxazole and trimethoprim but functions as sulfa monotherapy since P. carinii is apparently insensitive to trimethoprim. Dapsone, a sulfone, is a commonly used second-line agent. Both sulfamethoxazole and dapsone act by binding to dih...
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